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Neomycin, polymyxin, bacitracin, and hydrocortisone ophthalmic combination is used to treat and prevent eye infections caused by certain bacteria and to reduce the irritation, redness, burning, and swelling of eye inflammation caused by infection, chemicals, heat, radiation, foreign bodies in the eye, and other eye conditions. Neomycin, polymyxin, and bacitracin are in a class of medications called antibiotics. They work by stopping the growth of bacteria. Hydrocortisone is in a class of medications called corticosteroids. It works by activating natural substances in the eye to reduce swelling, redness, and itching.